Estrogen-deficiency Effect on the Composition of Dental Enamel: A Pilot Study

Background: Tooth enamel mineralization is assumed to be a target of endogenous estrogen imbalances. Objective: To evaluate the effect deficiency during amelogenesis on mineral composition dental enamel. Methods: Ten female Wistar Hannover rats were randomly divided into two groups according intervention received: ovariectomy surgery (OVX, experimental) and fictitious (SHAM, control). After 21 days, both euthanized, upper incisors extracted for analysis by energy-dispersive X-ray fluorescence. The sensitivity organ was evaluated in immunohistochemical odontogenic region lower presence receptors alpha beta (ERα ERβ, respectively) ameloblasts maturation stage. Differences between compared using Student’s t-test (P < 0.05). Results: No statistically significant difference detected OVX SHAM > ERα immunostained groups. Conclusion: Although express ERα, did not appear affect this murine model.